We are proud to spotlight our contribution to cutting-edge research with this comprehensive umbrella review and meta-analysis, which explores long-term mortality outcomes following conventional endovascular (EVAR) and open surgical repair (OSR) of infrarenal abdominal aortic aneurysm (AAA).
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This study applies a rigorous methodology, including the ROBIS tool for quality assessment, to evaluate published meta-analyses and conduct a de-novo meta-analysis of randomized controlled trials (RCTs). Key findings include:
- Short-Term Mortality: EVAR demonstrates significantly favorable mortality outcomes up to 4 years.
- Long-Term Mortality: No statistically significant difference was observed between EVAR and OSR beyond this period.
- Advanced Statistical Approaches: Both one-stage (Cox model) and two-stage analyses provide robust insights, with parametric modeling (generalized gamma) showing trends favoring EVAR over time.
- The results underline the nuanced understanding required to evaluate long-term outcomes and treatment strategies for AAA.
This publication highlights our expertise in systematic reviews, meta-analyses, and advanced evidence synthesis, areas integral to our service offerings.
- Systematic Literature Reviews (SLRs)
- Comprehensive evidence mapping using robust frameworks and quality assessment tools like ROBIS.
- Insights to support clinical decision-making and health technology assessments.
- Meta-Analyses and Individual Patient Data (IPD) Analyses
- De-novo meta-analyses of trial data, including reconstructed individual patient data (IPD).
- Application of advanced statistical methodologies, including one-stage and two-stage meta-analytical approaches.
- Advanced Statistical Modeling
- Expertise in parametric and non-parametric survival models to address complex research questions.
- Tailored solutions for nuanced and high-impact results.
- Evidence Dissemination
- High-quality deliverables designed for publication in prestigious journals, enhancing visibility and credibility of findings.
This publication demonstrates our ability to deliver research that resonates within the scientific and healthcare communities. With meticulous methodologies and a focus on high-impact outcomes, we can help you achieve similar success, whether through systematic reviews, meta-analyses, or health economic evaluations.
Let us help you advance your research and maximize its impact on healthcare decision-making.
