Stop bad inputs from sinking your ICER or budget impact
Get professional quality assurance for your health economic models with our rapid verification service. 24-hour input validation. 48-hour independent verification. Complete peace of mind before submission.
Supported platforms: Excel, R, Python, TreeAge
WHO WE SERVE
HEOR Leads, Health Economists, HTA Managers, RWE Leads, Outcomes Researchers, and Medical Directors in:
- Medical Devices
- Pharmaceuticals
- Healthcare Consulting
Across EU, UK, and US markets: especially when deadlines are tight and submissions must be defensible.
OUR SERVICES
Service A: Inputs-24™ (24-Hour Input Validation)
What We Check:
✓ Population & Epidemiology
- Cohort sizes, incidence/prevalence rates
- Inclusion/exclusion criteria vs. source documentation
- Population flow consistency
✓ Model Parameters
- Time horizon, cycle length
- Discount rates (costs & outcomes)
- Price year and currency consistency
✓ Cost Architecture
- Unit costs × resource utilization
- One-off vs. recurring costs
- Rebates, VAT, price caps
- Inflation indexing to target year
✓ Clinical Effectiveness
- Utilities and QALY calculations
- Risk ratio/odds ratio/hazard ratio conversions
- Baseline risk parameters
- Extrapolation methodology flags
✓ Uncertainty Analysis Setup
- PSA/DSA distributions and bounds
- Parameter correlations
- Random seed and iteration counts
✓ Technical Hygiene
- Units and labeling consistency
- Broken formula links
- Hidden circular references
- Sheet protection issues
Deliverables (24 hours):
- RAG-rated issue log (CSV) with severity levels and quick-fix recommendations
- Annotated model copy with clear correction markers (Excel/Sheets)
- Assumptions summary documenting scope and methods
Service B: Verify-48™ (48-Hour Full Verification)
What We Verify:
✓ Model Structure
- CEA state transitions and patient flows
- BIM budget allocation blocks
- Conservation principles and mass balance
- Markov trace validation
✓ Core Calculations
- Total costs and effects
- Incremental analysis (ΔCosts, ΔEffects)
- ICER/INMB calculations (CEA)
- Budget impact projections (BIM)
- Base case and scenario analyses
✓ Technical Accuracy
- Discount factor mathematics
- Half-cycle correction implementation
- Time-dependent transition probabilities
- Boundary conditions and edge cases
✓ Reimbursement Logic
- DRG/HRG tariff application
- Price list implementation
- Coding accuracy vs. documentation
✓ Probabilistic Analysis
- PSA convergence assessment
- Distribution sampling validity
- Correlation matrix application
- Extreme value detection
✓ Code Quality
- Formula consistency across sheets
- Macro and add-in dependencies
- Version control documentation
Deliverables (48 hours):
- Verification report (PDF) with findings, discrepancies, and recommendations
- Replicated results table comparing our calculations to model outputs
- Annotated workbook or code diff showing specific issues
WHY CHOOSE OUR QA SERVICE
Speed Without Compromise
- Deterministic verification – No AI-generated numbers
- Human expert review – Senior economists sign off
- Reference-locked – Every correction traced to source
- 24/7 processing – Global team ensures rapid turnaround
Platform Expertise
- Excel/Google Sheets (all versions)
- TreeAge Pro exports
- R (including Shiny apps and BCEA/heemod packages)
- Python (Jupyter notebooks, Streamlit apps)
- Note: We require runnable files with transparent formulas – no reverse-engineering of compiled binaries
TRANSPARENT PRICING (ex-VAT)
Inputs-24™ Service
Lite | ≤200 parameters | £890 Standard | ≤600 parameters | £1,500 Complex | >600 parameters | £2,400
Verify-48™ Service
Standard Excel/Sheets | ≤20 tabs | £3,900 Large/Code-Based | >20 tabs or R/Python | £4,900
Value Bundles & Add-Ons
Bundle Special | £4,900 | Inputs-24 + Verify-48 (same model, same week) PSA Re-run | £600 | Up to 2,000 simulations HTA Results Pack | £650 | Publication-ready tables and figures Rush Service | +25% | Weekend/holiday or <12-hour turnaround
HOW IT WORKS
Simple 5-Step Process
1. Submit Materials
- Send model files with passwords
- Include run instructions and input dictionary
- Specify price year, currency, and key sources
2. Inputs-24 Delivery
- Receive RAG-rated issue log
- Get annotated model with fixes
- Review assumptions documentation
3. Verify-48 Analysis
- Independent team recomputes results
- Structural validation performed
- Comprehensive report generated
4. Optional Corrections
- We apply unambiguous fixes (with permission)
- Provide detailed fix list for complex issues
- Document all changes made
5. Final Handover
- Clean artifacts for submission
- Audit trail documentation
- Ready for regulatory review
FREQUENTLY ASKED QUESTIONS
Q: Do you modify our original model?
We document all issues found. With your permission, we apply unambiguous fixes and provide a complete change log showing differences.
Q: Can you work in our secure environment?
Yes, we can work within your VDI or secure data room with appropriate access credentials.
Q: What about confidentiality?
We sign NDAs and DPAs as standard. EU data residency guaranteed. No patient-level data processed.
Q: What if sources are behind paywalls?
Please provide PDFs or access credentials. Otherwise, we flag items as “pending verification” and suggest open-access alternatives.
Q: Do the 24/48 hours include weekends?
Standard service covers business days (CET). Weekend and holiday service available with 25% rush fee.
Q: How do you handle very large models?
Pricing tiers are based on tab count, parameter complexity, and computational requirements. We provide rapid scoping within 2 hours.
COMPLIANCE & QUALITY ASSURANCE
Our AI Policy
✓ AI assists with reference location and documentation
✗ AI never generates or modifies numerical results
✓ All calculations are deterministic and reproducible
✓ Every number is source-verified and human-reviewed
Quality Standards
- ISO 9001 quality management principles
- ISPOR good practices compliance
- NICE/SMC/HAS technical requirements awareness
- Two-reviewer sign-off on all deliverables
CLIENT SUCCESS STORIES
“Caught a critical discounting error that would have delayed our NICE submission by months”
– HEOR Director, Top-10 Pharma
“The 24-hour input check saved our HTA submission, found unit mismatches we’d missed in three internal reviews”
– Market Access Lead, Medical Device Company
“Their verification report gave our board confidence in our €5M budget impact projections”
– CEO, Biotech Startup
NEXT STEPS
Ready to secure your submission?
[Download Free QA Checklist]
Our comprehensive model review checklist used by HTA experts
[Book 15-Minute Consultation]
Walk through your model requirements and timeline
[Get Instant Quote]
Upload your model structure for immediate pricing
CONTACT US
Biomath Models
Healthcare Economic Model Verification
Email: sales@biomathmodels.org
Phone: +44 20 3239 1940
Address: 27 Old Gloucester Street, London WC1N 3AX, UK
Available: Monday-Friday 9:00-18:00 CET
Rush Service: 24/7 with prior arrangement
Make your next submission bulletproof: 24 hours for input validation, 48 hours for complete verification. Because your ICER is too important to leave to chance.
